الفهرس 
Effect of preoperative, single-dose amoxicillin/clavulanic acid combination on postoperative endodontic pain in patients with symptomatic apical periodontitis: A double-blind randomized controlled trial
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Abstract
The purpose of this randomized, double-blind, controlled study was to assess the effect of a
single-dose of amoxicillin/clavulanic acid premedication on postoperative pain following
endodontic treatment in patients with symptomatic apical periodontitis.
Methodology: Seventy-two patients aged 18-60, with symptomatic apical periodontitis were
randomized into an experimental group where patients received 2 gm of amoxicillin/clavulanic
acid, and a control group where patients received a placebo 30 minutes before endodontic treatment.
All patients underwent endodontic treatment in a single visit then were asked to record their level of
pain following treatment using the 11- point numerical rating scale (NRS) at 6, 12, 24, 48, 72-h and
7 days following the treatment. They, also, recorded their analgesic intake, swelling and any
adverse events that occurred.
Results: There was no difference in pain incidence between the two groups at the 6-, 12- and 24-h
and 7-day time points postoperatively (p > 0.05). At the 48- and 72- h time points, pain was less in
the amoxicillin/clavulanic acid group (p < 0.05). There was no difference in pain on biting
between groups at the 6-, 12-, 24-, 48-h and 7-day time points postoperatively (p > 0.05), however,
at the 72-h time point, pain was less in the amoxicillin/clavulanic acid group (p < 0.05). There was
no difference in the incidence of analgesic intake between groups (p > 0.05). No patients reported
the occurrence of swelling nor adverse events.
Conclusion: Amoxicillin/clavulanic acid premedication may help reduce postoperative pain at 48-
and 72-h following endodontic treatment in patients with symptomatic apical periodontitis treated in
one visit