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Abstract Hepatocellular carcinoma (HCC) is the fifth most common cancer, it is frequently secondary to infections with hepatitis viruses. Liver resection is one of the preferred therapeutic options for patients with HCC, it’s still associated with postoperative morbidity and mortality, especially in patients with underlying chronic liver disease. There are several diagnostic tests available to assess reserved liver function in patients undergoing liver resection, a low platelet count serves as a noninvasive indicator of portal hypertension, however, the value of a low preoperative platelet count to predict perioperative outcomes is not well defined in patients undergoing resection for HCC. Our study was done to evaluate the effect of preoperative platelet count on the operative and early (short-term) postoperative outcomes of minor liver resection for patients with HCC. This is a prospective comparative study, it was held on National Liver Institute, Menoufia University between the period of January 2018 and December 2022, it included 75 patients who underwent elective minor liver resection for HCC, patients were divided into two groups, group A included 25 patients with low preoperative platelet count (˂100×103 / mm3), and group B included 50 patients with normal preoperative platelet count (≥100×103/ mm3). Preoperative evaluation was done to all patients including laboratory and radiological investigations, operative data were recorded, and postoperative follow up was done with assessment of complications and overall morbidity |