الفهرس 
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Abstract
Women of diminished ovarian reserve constitute a significant number of women referred for IVF treatments (ranging from 9 to 24 %), most of them are old age. Attempts to improve IVF cycle outcomes for PORs. Final oocyte maturation trigger is one of the most vital success elements in assisted reproductive technologies (ARTs). The authors in this study sought to investigate the role of dual trigger in final oocyte maturation in PORs undergoing GnRH-antagonist ICSI cycles.
A prospective randomized controlled trial conducted on 160 PORs indicated for ICSI. They were randomized to either group (A) or group (B). group (A) received 10000 IU of hCG (Choriomon5000 IU; IBSA) given intramuscularly while group (B) received 10000 IU of hCG (Choriomon5000 IU; IBSA) intramuscular injection in addition to the GnRH agonist triptorelin 0.2 mg (Decapeptyl 0.1 mg; Ferring) subcutaneously for triggering of ovulation. The primary outcome was the number of retrieved metaphase II oocytes. Secondary outcomes included the total number of oocytes, ratio between number of follicles seen on day of trigger and number of oocytes retrieved, maturity index and fertilization rate.
The results of the present study showed that dual trigger was associated with higher number of fertilized oocytes (3.3±1.81 vs. 3.92±1.90, p=0.039), fertilization rate (80.82±23.04 vs 91.86±15.62, p=0.002) and maturity index (81.5% vs 86.9%, p=0.043). There were no significant differences in terms of the total number of oocytes retrieved and the number of metaphase 2 oocytes.