الفهرس | Only 14 pages are availabe for public view |
Abstract Alopecia areata (AA) is a common, non-scarring dermatological condition regularly distinguished by patches of hair loss on the scalp and other hairy areas. Alopecia areata does not distinguish genders. It affects both children and adults and hair of all colors. Alopecia areata frequently occurs in association with other autoimmune diseases such as thyroid disorders, anemia and other skin disorders with autoimmune etiology. Alopecia areata is a complex disease arising from the concerted action of multiple genes and is possibly influenced by environmental factors as well. (IL32) is pro-inflammatory cytokine. Its expression is elevated in various inflammatory autoimmune diseases, certain cancers, and viral infections. A gene polymorphism also called “sequence variant” is a permanent change in the DNA sequence that makes up a gene. This type of genetic change used to be known as a gene mutation, but because changes in DNA do not always cause disease, it is better called gene variant. Single nucleotide polymorphisms (SNPs) of the interleukin-32 gene has recently been associated with development of different autoimmune disease as Ankylosing spondylitis , Crohn disease , Psoriatic arthritis , Ulcerative colitis and Multiple sclerosis . So, our study aimed to detect the genetic variations of IL-32 (rs 12934561) gene and the susceptibility for developing Alopecia areata. Our study included (25) patients suffering from psoriasis (group A) from the outpatient clinic of Dermatology Department of Beni-Suef University Hospital and (25) apparently healthy individuals of matched age and sex as a control group (group B) We found that there is no statistically significant differences in genotypic distribution of (rs12934561) among Alopecia areata cases and control group regarding all types of genotypes (TT, TC & CC) but genotype CC is slightly higher in patient group than in control group (40% & 16%) respectively. |