الفهرس 
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Abstract
Doxorubicin (DOX) is an anticancer drug that had cardiotoxic effects. Metformin (Met) is an orally used first-line anti-diabetic drug for the treatment of diabetes. Omega-3 is an essential biochemical constitutes that showed several biomedical potentials. This study evaluated the usefulness of Metformin and omega-3 on DOX-induced cardiotoxicity in rats. Rats were divided into five groups (n=10) as follows; normal control group (G1): rats was given drinking tap water and normal experimental pelleted animal food ad libitium and distilled water daily for one month. DOX group (G2) rats were injected i.p with DOX (4 mg/kg) once a week for a month. DOX/Met group (G3) rats were injected with DOX as in G2, and administered with Met (200 mg/kg) daily for a month. DOX/Omega-3 group (G4) rats were injected with DOX as in G2, and administered orally by gavage with Omega-3 (200 mg/kg) daily for a month. DOX/Met/Omega-3 group (G5) rats were injected with DOX as in G2, and administered with a combination of Met and Omega-3 as in G3 and G4. At the end of the experiment, all groups were sacrificed. The percentage of body weight changes were determined, blood and sera were collected for hematological and biochemical analyses. Heart tissues of each group were isolated for determination of the oxidative stress biomarkers and histopathology. The results showed that combination of met and omega-3 treatment led to improvement of cardiotoxicity induced by DOX in male rats evidenced by significant enhancement in hematological, antioxidant and histopathology.