الفهرس 
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Abstract
Copper oxide nanoparticles (CuONPs) have a wide range uses in agricultural applications. Nano-Curcumin (NCur) acts as antioxidant treatment. The goal of study is to reduce the toxicity resulting from the use of CuONPs as nano-pesticides on living organisms by inducing changes on morphological shape of CuONPs or treating it with NCur. So, we induced a comparative study between three shapes of CuONPs as CuO NanoSphere (CuONSp), CuO NanoSheet (CuONS) and CuO NanoFlower (CuONF). We characterize each nano-form by using X-ray diffraction (XRD), scanning electron microscope (SEM), transmission electron microscope (HRTEM) and Zeta sizer-HT device.
36 rats divided to six groups (n=6), 1st gp control gp. 2ed gp received 50 mg/kg/day of NCur orally 30 days. 3th, 4th & 5th gps received orally 50 mg/kg/ day of CuONSp, CuONS& CuONF respectively 30 days. 6th gp received 50 mg / kg/ day CuONSp plus 50 mg / kg/ day of NCur orally 30 days. An elevation occurred in malondialdhyde (MDA), liver and kidney functions, tumor necrosis factor- alfa (TNF- α) and B-cell lymphoma 2 (Bcl2) by CuONSp > CuONS > CuONF respectively. An inhibition occurred in glutathione (GSH), superoxidase (SOD) catalase (CAT), apoptotic Bax gene (Bax), histopathological and ultrastructural alterations by CuONSp< CuONS< CuONF respectively. NCur ameliorated these alternations. In conclusion, CuONF is a better form compared to other forms as nano-pesticide in agriculture due to its lower toxicity. NCur decreased the biological alternations which induce by CuONSp due to its antioxidant and anti-apoptotic properties.