الفهرس 
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Abstract
Atopic dermatitis (AD) is a chronic, relapsing and pruritic inflammatory skin disease, characterized by typical localization and a specific image of skin lesions, with coexistence of other atopic diseases. Pruritus is one of the most common symptoms in AD, practically occurring in each patient. The incidence of such atopy has been increasing over the last decades, especially in industrialized countries, maybe due to external factors, which foster lesions severity and consequently bring some difficulties to adaptation to school, social and family life.
Endoplasmic reticulum aminopeptidase 1 (ERAP1)belongs to the M1 family of zinc metallopeptidases, responsible for trimming peptides for HLA class I presentation and also cleave proinflammatory cytokine receptors (TNFR1, IL-1 RII and IL-6 Rα), eventuating in the downmodulation of their signal intensity on the cell surface. Therefore, the current study aimed to investigate the role of Endoplasmic Reticulum Amino Peptidase 1 gene polymorphism (ERAP1 rs26618) in atopic dermatitis. The study was performed on 25 patients with atopic dermatitis from both sexes and different age. Patients were collected from Dermatology outpatient clinic Menoufia University hospital during the period from October 2019 to March 2021.In addition to 25 healthy subjects as a control group.
All patients were selected according to the inclusion and exclusion criteria: Inclusion criteria including Children with age <18 years, both sexes, diagnosis of atopic dermatitis established by a dermatologist according to clinical features and patients with no history of receiving any systemic treatment in the past 6 weeks or topical treatment in the past 2 weeks. Exclusion criteria including Participants with any of the following systemic disease were excluded (diabetes mellitus, heart failure, hypertension, infections such as (HIV, HPV, LCMV), autoimmune diseases, or other immunological disorders.
All patients in the study were subjected to: full History taking, clinical examination including (Complete general examination and dermatological examination) and endoplasmic reticulum aminopeptidase 1 ERAP1 rs26618 gene polymorphism study using Taqman Allelic Discrimination assay technique (real time PCR) .
Results of the current study can be summarized as follows:
• There was no significant difference between atopic dermatitis patients and control groups regarding age.
• ERAP1 rs26618 CC genotype, dominant model and C allele were significantly associated with risk of atopic dermatitis.
• No significant relations were found between ERAP1 rs26618 genotypes with age, gender, duration, and clinical data.
• ERAP1 rs26618 CC genotype, was significantly associated with risk of higher SCORAD score in AD patients, accordingly this genotype predict the more severe form of the disease.