الفهرس | Only 14 pages are availabe for public view |
Abstract The present study was conducted to 1) check out whether baicalien can enhance the anticancer effects of capecitabine in MCF-7 cell lines, 2) evaluate the possible mechanism through which capecitabine induces cardiotoxic effects in rats, and the potential protective role induced by the concurrent administration of baicalein. This was attained by evaluation of i) some biochemical parameters, total antioxidant capacity, and proinflammatory cytokines; ii) cardiac oxidant/antioxidant status; iii) the expression pattern of nuclear factor kappa B (NF-κB), toll-like receptor 4 (TLR4), myeloid differentiation primary response 88 (MYD88), activating transcription factor 6 (ATF6), C/EBP homologous protein (CHOP), and c-Jun N-terminal Kinase (JNK); and 4) histological alterations of cardiac tissue. |