الفهرس 
Chemistry of quinazolineOnly 14 pages are availabe for public view
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Abstract
ENGLISH SUMMARY
This research aimed to synthesize some peptides from quinazoline derivatives and study their biological activity.
Therefore, compound 1 was reacted with 1,2,4-triazole in the presence of triethylamine and phosphorus oxychloride to yield compound 2, which was converted to the corresponding amine derivative 3 by boiling in ammonium hydroxide and dioxane.
Compound 3 was reacted with ethylchloroacetate in acetone to obtain the corresponding ester compound 4 in yield of 70%, which was converted to the corresponding hydrazide by boiling in hydrazine hydrate to obtain the compound 5 with a yield of 86%.
Hydrazide 5 was converted to the corresponding azidic acid by reaction with sodium nitrite and then directly reacted with amino acid esters to obtain peptides 6 and 7 with a yield of 75-80%, respectively.
The peptide esters were converted to the corresponding hydrazides by boiling in hydrazine hydrate , yielding compounds 8 and 9, respectively (Scheme 1).