الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Literature survey of transition metal complexes derived from aliphatic, heterocyclic, and aromatic hydrazides was reported. The biological activities of hydrazides, and their metal complexes are the main goal in their investigation. Due to the existence of different donor atoms (O and N donors), which display unique bonding modes and lead in various structural designs, and hence hydrazides are currently of great interest.The current thesis’s primary goal is to synthesize two novel ligands known as, N-ethyl-2-(2-hydrazinyloxoacetyl) hydrazine-1-carbothioamide (L2), and 2,2’-oxalylbis-(N-ethylhydrazine-1-carbothioamide (L3), in addition to their complexes of Pd(II), Ni(II), Cu(II), Zn(II), and Co(II) metal ions. Elemental analyses, thermal (TGA and DTGA), spectral (IR, UV-Visible, EPR, 1H-NMR, 13C-NMR), and magnetic measurements were used to characterize the isolated solid compounds. Also, conductance titrations, molecular computational calculations, and biological activities are investigated in details.The total work of this thesis can be summed up as follows in brief:The first chapter featured many papers deals with the complexes of hydrazides, with a focus on compounds comparable to these examined, and their biological functions.he second chapter describes and illustrates the experiments employed in the present study. A list of reagents and stock solutions, as well as physical measurements and equipment are reported. Also, it includes the working processes and a description for preparing the ligands and their metal complexes. This chapter also provided the recommended protocols for testing the produced compounds against anti-microbial, and anti-cancer activities.
Chapter three exhibits the results and discussion which are summarized to give the following information.1.The proposed chemical formulae for the ligands and their metal complexes are quite agreeing with the stoichiometry derived from their micro analytical results (carbon, hydrogen, nitrogen, sulfur, chloride, and metal).2. All the isolated solid complexes have high melting points (>300˚C) except for the Cu(II) complexes (261-284 ˚C). All the complexes are insoluble in most organic solvents, but some of the complexes are soluble in DMSO.3. Using IR spectra, the coordination sites of the ligands, the makeup of metal-ligand bonds, and the presence of solvated molecules were all clarified. Based on a careful comparison of the spectra of the examined ligands and their associated complexes, various ways of chelation are proposed for the ligands. The gathered information is condensed into:<ODH acts as:i.A binegative tetradentate ligand via the two (C=N)az. and the enolized of both (C=O) groups in case of Pd(II) and [Co(ODH-H)2(H2O)2] (4) complexes.ii.A mononegative bidentate ligand via the two (C=N)az. and the enolized of (C=O) groups in case of Ni(II) and Co(II) complexes.
L2 acts as: i.A binegative tetradentate through both (C=N)az. and both oxygen atoms of the deprotonated enolic carbon in Pd(II) and [Cu3(L2-2H)3(H2O)7MeOH].MeOH (8) complexes, binegative tetradentate through (C=N)az. and both oxygen atoms of the deprotonated enolic carbon and through the nitrogen of (CONH) group. And bi-negative tridentate via the (C=N)az. and oxygen atom of the deprotonated enolic carbon and the deprotonated sulfur of isothiocyanate group in case of [Cu3(L2-2H) (H2O)7MeOH].MeOH (8).ii. A mononegative bidentate ligand via the two (C=N)az. and the enolized of both (C=O) and (C=S) groups, and through the nitrogen of (CONH) in [Cu2(L2-2H) Cl2(CH3OH)H2O].CH3OH (10) complex. iii.A neutral tridentate ligand coordinated through the enolized (C=O) and the (C=N) groups in case of [CoL2Cl2(CH3OH)2] (11).iv.A binegative bidentate ligand coordinated through the enolized two (C=O) groups in case of Zn(II) complex.L3 acts as:i. A binegative tridentate ligand via two (C=N)az. and the enolized of both the (C=O), (C=S) groups in case of [Cu2(L3-H)(H2O)4].½CH3OH (15).ii.A binegative tetradentate ligand through the two nitrogen of (CONH) and the enolized two (C=S) groups in case of [Cu(L3-2H)] (16), and [Ni(L3-2H)] (18).iii.A mono-negative tridentate ligand via the two (C=N)az. and the enolized of both the (C=O), (C=S) groups, and through the nitrogen of (CONH) group in case of [Cu2(L3-H) Cl3H2O].H2O (17) complex.iv.A binegative tri-dentate ligand through the two (C=N)az. and the enolized of both (C=O), (C=S) groups in case of [Co(L3-2H)(H2O)2].2H2O (19).v.A neutral tridentate ligand through the (C=O) oxygen, (C=S) sulfur atoms and the nitrogen atom of (CONH) in the complex with the formula, [ZnL3(CH3OH)1½(H2O)½]Cl2 (20).vi. A neutral bidentate ligand via the (C=O) and (CONH) groups in the [PdL3(H2O)2] (21) complex.4.The geometries of [Cu3(L2-2H)3(H2O)7CH3OH].CH3OH (8), [Cu2(L2-2H) Cl2(CH3OH)H2O].CH3OH (9), [Cu(L3-2H)] (16), [Cu2(L3-4H)(H2O)4].½CH3OH (15), [Cu2(L3-H)Cl3H2O].H2O (17) complexes are elucidated using EPR spectra confirming an elongated octahedral, tetrahedral, tetrahedral, square-pyramidal and square-pyramidal geometries for the complexes, respectively.5The thermal examination of the produced compounds was carried out at temperatures ranging from 30 to (912, 1020) degrees Celsius. For some complexes, the temperatures depicted the decomposition phases. The observed constant weight corresponding to the complex’s residual portion after decomposition.>6.The molar conductivity of the complexation L1, L2, and L3 with chloride salts of Pb2+, Co2+, Zn2+, and Ni2+ at a temperature (25 ± 1.0 ºC) and in 50 % (v/v) aqueous–ethanol solution with L2 and L3, and in H2O with ODH was found to be changed with the function of mole-ratio of ligand and metal ions. 7.The last part of this chapter includes a study of the biological effect of the complexes that have been prepared as antibacterial, antifungal, anticancer, and antioxidants, as well as their effect on protein and wound healing of HepG2 cell line cancer cell.