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العنوان
Classic and Combined Approaches in Surgical Strategies for Management of Synchronous Colorectal Liver Metastasis /
المؤلف
Elsebaey, Ahmed Alaa Adel Ali.
هيئة الاعداد
باحث / احمد علاء عادل علي السبيعي
مشرف / أبوبكر محمد محي الدين
مشرف / اشرف عبد العظيم محمد
مشرف / محمد عبد الرحيم عليان
الموضوع
Surgery. Surgical oncology.
تاريخ النشر
2023.
عدد الصفحات
136 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
جراحة
تاريخ الإجازة
18/9/2023
مكان الإجازة
جامعة المنيا - كلية الطب - الجراحة
الفهرس
Only 14 pages are availabe for public view

from 137

from 137

Abstract

The second leading cause of cancer-related death worldwide and the third most common cancer overall is colorectal cancer. The liver is where colorectal cancer metastases occur most often. A liver metastasis will develop in around 50% of colorectal cancer patients during the course of their illness, with 15 to 25% already having it when their colon tumor was first discovered. It’s important to know if liver metastasis from colorectal cancer was found before, during, or after the disease was diagnosed (”synchronous colorectal liver metastasis”) or after the main tumor was removed (”metachronous colorectal liver metastasis”). Because of improvements in imaging technologies, synchronous colorectal liver metastasis is becoming more common than metachronous colorectal liver metastasis. In terms of long-term survival or even full recovery, surgery is the most successful therapy for individuals with colorectal liver metastases; the 5-year survival rate after surgery is between 30–50%. There are three surgical methods for treating synchronous colorectal liver metastasis: a) the traditional ”staged” method, which involves removing the primary colorectal tumor first, then the liver metastasis; b) the combined ”simultaneous” method, which involves removing the primary colorectal tumor and liver metastasis in the same operation; and c) the reverse ”liver-first” method, which involves removing the liver metastasis The ideal surgical technique is still up for debate and depends on the state of the individual patient as well as institutional protocol. The outcomes of surgery for colorectal cancer liver metastases will be measured and assessed in this research utilizing both conventional and cutting-edge methods. This study’s objective is to evaluate the short-term results of colorectal cancer liver metastasis surgery at 6 months utilizing both conventional and combined methods. This retrospective study examined the immediate effects of surgical treatment for colorectal liver metastases. In this study, patients with synchronous colorectal liver metastases who had surgery using standard and combination techniques were included.
The main results of the study revealed that:
• In terms of demographic information, there is no statistically significant difference between the groups.
• The groups do not vary statistically significantly from one another.
• In terms of laboratory measurements, there is no statistically significant difference between the groups.
• There is no statistically significant difference in liver biopsy results across the groups.
• In terms of the child score, performance, or chemotherapy, there is no statistically significant difference between the groups.
• The surgical time and blood loss vary significantly amongst the groups.
Thus, compared to the staged group, the combined group’s operative time and blood loss were significantly higher (P=0.015 and 0.031, respectively).
• There is no statistically significant difference in the need for blood transfusions across the groups.
• In terms of the location of colorectal lesions, there is no statistically significant difference between the groups.
• There is no statistically significant difference in the location of the liver lesion between the groups.
• There is no statistically significant difference between the groups in terms of the kind of colorectal resection or the type of liver resection.
• In terms of issues, there is no statistically significant difference between the groups.
• The histology is not significantly different across the groups.
• Two patients passed away in the staged group, compared to one in the combined group. The groups don’t, however, vary much from one another.