الفهرس 
INTRODUCTION AcneOnly 14 pages are availabe for public view
 |  | from | 113 |  |  |
| | | from | 113 | | |
Abstract
Acne vulgaris is a chronic inflammatory skin disease of pilosebaceous
units affecting skin areas with dense population of sebaceous follicles such as the
face, upper chest and back.
Acne is characterized by non-inflammatory (open or closed comedones)
and inflammatory lesions (papules, pustules, or nodules).
Mammalian target of rapamycin is a nutrient‐sensitive regulator of
cellular growth and proliferation, lipid synthesis and protein translation, exerting
its effects through two distinct signaling complexes: mTORC1 and mTORC2.
In particular, rapamycin‐sensitive mTORC1 promotes cell growth and
proliferation, which may translate into proliferation of acroinfundibular
keratinocytes and increased lipid biosynthesis in sebaceous glands, which are
responsible for seborrhea. Conversely, mTORC2, which is non-sensitive to
rapamycin, is involved in the regulation of cell polarity and in the functional
phosphorylation of cytoskeleton actin fibers.
Multiple diseases, either neoplastic, dysmetabolic or inflammatory, show
dysregulation of mTOR pathway, which might be also involved in inflammatory
skin diseases such as psoriasis, atopic dermatitis and allergic contact dermatitis.
Acne appears to develop in metabolic environments with increased mTORC1
signaling, and has been proposed to represent a visible mTOR‐driven disease of
civilization.The aim of this study was to use mTOR gene expression as a prognosticmolecular marker to detect severity of acne, minimize complication and improvequality of life. -