الفهرس 
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Abstract
ABSTRACT
This prospective cross-sectional study recruited 26 CKD-5d children on regular HD three hours thrice weekly attending PDU, Children’s Hospital, Ain Shams University to assess the effect of a single HD session on the level of circulating NETs. They were evaluated pre and post-dialysis then compared to 26 age and sex-matched healthy control group.
There were no significant differences between both groups regarding mean age (p=0.089) and sex distribution (p=0.289). The cause of ESRD was unknown in 30.77%, CAKUT in 26.92%, glomerulopathy in 23.08%, ARPKD in 7.69%, Joubert syndrome in 7.69% and Alport syndrome in 3.85%. The duration of HD therapy ranged from 5.9 to 109.5 months with a median of 35.5 months and IQR of 32.6 months. All cases were dialyzed using low flux polysulfone membrane.
The FSA was 1 m2 in 61.54%, 0.8 m2 in 34.62%, and 0.2 m2 in 3.85% of the cases. The BFR was 250 ml/min in 53.85%, and 200 ml/min in 46.15% of the cases. 53.85% of the cases were hypertensive. Our study revealed that children with CKD-5d on regular HD had a statistically significant higher basal (pre-HD) levels of circulating NETs than normal controls (p<0.001). These levels were further increased after HD session to statistically significant higher values than pre-HD level (p<0.001) and controls (p<0.001).
No significant correlations were found between NETs and any of the studied variables including age, duration of HD, total leukocyte count, absolute neutrophil count, and lymphocyte count.