الفهرس 
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Abstract
Abstract
Infection with fowl adenoviruses (FAdVs) can lead to a number of syndromes in chickens. These syndromes, which include inclusion body hepatitis (IBH) and hepatitis-hydropericardium syndrome (HHS), as well as others, are responsible for tremendous economic losses all over the world. FAdVs can be divided into a total of twelve different serotypes and five different species (A–E; 1–8a and 8b–11). As a result of the extensive distribution of FAdV strains, the vast majority of bird species are susceptible to infection. IBH and HHS are both caused by viruses belonging to the genus aviadenovirus, which is a family within the adenoviridae viral family. In our study samples from IBH and HHS suspected outbreaks were collected from Alexandria, Matroh and Behera governorates. The affected broilers showed enlarged liver and kidney accompanied with straw-colored fluid accumulates in the pericardial sac around the heart. The FAdVs infection confirmed by conventional PCR infection using Hexon gene specific primers then sequencing of five selected FAdv the isolates. Phylogentic analysis of the obtained sequences in comparing with reference strains from gene bank showed that the isolates were highly similar to the circulating FAdV type D in Egypt with nucleotide identity ranged 99 -100% and amino acid identity ranged 97.2-100%. While they are of low similarity with the other FAdV serotypes located in group D FAdV. Interestingly we found that FAdV species D was predominant in Egypt now especially FAdVs- 2/11.
Key words: FAdV-4, sequencing analysis, histopathology, broiler chickens