الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
T1D is considered a multifactorial disease with a background of autoimmunity. Its prevalence is rising among children and adolescents. About 35 million people worldwide have T1D with an annual increase of 3-5%. It is one of the most common chronic diseases among children and strongly associated with increased risk of microvascular disease, including DPN, DR, and DKD.
FG is the major protein of the coagulation system, which is a soluble, homodimeric glycoprotein. FG is made up of 3 polypeptide chains in 2 pairs (alpha, beta, and gamma) where their genes are located on chromosome 4q28. FG exhibits pleiotropic biological functions owing to its various binding sites. Moreover, it has the capability of binding to a range of adhesion molecules or receptors presented on immune, hematopoietic, and neuronal cells. Being an acute phase reactant, FG has proved to have an important role in inflammation.
Recent studies have focused on FGB gene polymorphism (e.g., rs1800790, -455G/A) as its synthesis is the rate limiting process for FG synthesis.
There is paucity of data regarding the relation between FG gene polymorphism and different microvascular complications in T1D.This invited us to conduct the present study. The aim of our study was to genotype FGB (rs1800790) polymorphism in patients with T1D and to determine its relation to microvascular complications in young subjects with T1D.
One hundred T1D patients were enrolled in the present cross-sectional study, aged 6–19 years with diabetes duration ≥3 years. Patients with diabetes duration less than 3 years, T2D. Pregnancy, severe renal or hepatic impairment and patients with history of cardiovascular disease were not allowed to participate in the study.