الفهرس 
Serum Albumin and Jaundice in Premature NeonatesOnly 14 pages are availabe for public view
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Abstract
This was a cross-sectional study conducted on 198 preterm neonates, number of males was 125 and number of females was 73 with mean of age at admission 2.38 ±1.77 days and 66 apparently healthy preterm neonates (controls), number of males was 42 and number of females was 24 with mean of age at admission 1.00 ±0.0 days who attended to neonatal intensive care units (NICU) of Menoufia University Hospital and Elshohdaa Central Hospital in the period from June 2022 to November 2022.
According to complications of prematurity, preterm neonates were divided into four groups, each group includes 66 preterm neonates:
1. group 1: Preterm neonates with neonatal jaundice either physiological or pathological. Number of males was 46 while number of females was 20 with mean of age at admission 3.79 ±1.35 days.
2. group 2: Preterm neonates with neonatal sepsis diagnosed according to sepsis score related to clinical signs such as temperature instability, Apnea, tachycardia or bradycardia and feeding intolerance plus CRP≥ 6, ≥ 2 altered serum parameters, and positive blood culture). Number of males was 40 while number of females was 26 with mean of age at admission 2.32 ±1.94 days.
3. group 3: Preterm infants with respiratory distress with tachypnea, expiratory grunting, nasal flaring, retractions (subcostal, subxiphoid, intercostal, and suprasternal) and use of accessory muscles, as well as cyanosis and poor peripheral perfusion. Number of males was 39 while number of females was 27 with mean of age at admission 1.03 ±0.17 days.
4. group 4: Apparently healthy preterm neonates (Control Group). Number of males was 42 while number of females was 24 with mean of age at admission 1.00 ±0.0 days.
All the participants were subjected to the followings:
1. Detailed personal and maternal history taking.
2. Assessment by Ballard score.
3. Complete general and systemic clinical examination.
4. Laboratory investigations
Complete blood count (CBC).
Serum Albumin Level and C-reactive protein.
Capillary blood gases: pH, PCO2, HCO3, PO2, and O2saturation.
Total serum bilirubin.
Chest X-ray if needed.
Blood culture if needed.
The following results were obtained:
There was a statistically significant difference between studied preterm neonates with jaundice and controls regarding TSB, haemoglobin level, platelets count and serum albumin level (p-value<0.05), but there wasn’t a statistically significant difference between studied preterm neonates with jaundice and controls regarding WBCs count (p-value>0.05).
At cut off point 3.05 the sensitivity and specificity of serum albumin in prediction of jaundice prognosis in preterm neonates was 86% and 68% respectively.
There was a statistically significant difference between studied preterm neonates with sepsis and controls regarding haemoglobin level, WBCs count, platelets count, NLR, serum albumin level, CRP and culture (pvalue<0.05).
There was a positive significant correlation between serum albumin level and both of haemoglobin level and platelets count, but there was a negative significant correlation between serum albumin level and WBCs, CRP and NLR in studied preterm neonates with sepsis (p-value<0.05).
At cut off point 2.95 the sensitivity and specificity of serum albumin in prediction of sepsis prognosis in preterm neonates was 100% and 75% respectively.
There was a statistically significant difference in serum albumin level between alive and dead preterm neonates with sepsis and respiratory distress where it was lower in dead preterm neonates (p-value<0.05).
There was a statistically significant difference between studied preterm neonates with respiratory distress and controls regarding PH, HCO3, O2 saturation and serum albumin level (p-value<0.05) where they were lower in cases, but there wasn’t a statistically significant difference between studied preterm neonates with respiratory distress and controls regarding PCO2 and PO2 (p-value>0.05).
There was a positive significant correlation between serum albumin level and PH, HCO3, PO2 and O2 saturation, but there was a negative significant correlation between serum albumin level and PCO2 in studied preterm neonates with respiratory distress (p-value<0.05).
At cut off point 2.95 the sensitivity and specificity of serum albumin in prediction of respiratory distress prognosis in preterm neonates was 100% and 75% respectively.
from the results of this study, we can conclude that there is relation between serum albumin level and prognosis of prematurity complications, so it is recommended to measure serum albumin level as a routine investigation in prematurity.