الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Hyperparathyroidism is overproduction of parathyroid hormone and its impact on calcium homeostasis, leading to bone disease and increase fracture risk. Hyperparathyroidism is subdivided into primary, secondary and tertiary.
Parathyroidectomy could be done through a bilateral neck exploration approach or a focused technique with intra-operative PTH assay. DROP of PTH level up to 50% is accepted.
Hungry bone syndrome is a less common post operative complication but dangerous which is diagnosed by hypocalcemia of less than 8.4 mg/dl (2.1mmol/L) for more than the fourth day post parathyroidectomy associated with hypophosphatemia.
This comparative study was conducted at the Head, Neck, and Endocrine surgical unit of the Alexandria Main University Hospital during the period from December 2021 to March 2023. We analyzed data from 52 patients who underwent parathyroidectomy: 32 for primary and 20 for secondary hyperparathyroidism. During short-term follow-up, many factors were examined to predict which patient subgroup could be at high risk for the development of HBS.
The occurrence of postoperative HBS was 50% for PHPT and 40% for SHPT in this study but there was no statistically significant difference between both groups. Both groups showed female predominance, and similar age distribution.
Total weight of resected parathyroid glands, and operative time were significantly higher in HBS group than those in non-HBS group in both PHPT and SHPT groups, while preoperative bone density measured by DEXA scan were significantly lower in HBS group than those in non-HBS group. Preoperative intact parathyroid hormone (iPTH) and radiological evidence of bone disease were only significant in HBS in PHPT but not in SHPT. Age at surgery, duration of complaint, Preoperative total calcium, intraoperative PTH DROP percentage, and were not associated with postoperative HBS.