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Abstract Summary i SUMMARY Chalcone 3 was synthesized by a base-catalyzed Claisen-Schmidt reaction between p-chlorobenzaldhyde and N-(4- hydroxyphenyl)acetamide in 70% yield (Scheme 1). The pyrimidine derivative 4 was obtained by refluxing 3 with urea in alkaline medium / ethanol in 68% yield (Scheme 2). Summary ii The ester derivative 5 was obtained by refluxing 4 with ethyl chloroacetate in alkaline medium / acetone in 72% yield (Scheme 3). Hydrazinolysis of 5 with hydrazine hydrate in ethanol afforded hydrazide derivative 6 in 66% yield (Scheme 4). The thiopyrimidine derivative 7 was obtained by refluxing 3 with thiourea in alkaline medium / DMF in 68% yield (Scheme 5). Summary iii The ester derivative 8 was obtained by refluxing 7 with ethyl chloro acetate in alkaline medium /acetone in 72% yield (Scheme 6). Hydrazinolysis of 8 with hydrazine hydrate in ethanol afforded hydrazide derivative 9 in 66% yield (Scheme 7). Sugar hydrazone 10 was obtained in 65% yield after refluxing of 6 with D-(+)-glucose in ethanol and in the presence of a catalytic amount of acetic acid. Thiadiazol 11 was obtained in 65% yield after refluxing of 6 with carbon disulfide in methanol and in the presence of a sodium methoxide (Scheme 8). Summary iv The ester derivative 12 was obtained by refluxing 11 with ethyl chloro acetate in alkaline medium / acetone in 72% yield (Scheme 9). Sugar hydrazone 13 was obtained in 65% yield after refluxing of 9 with D-(+)-glucose in ethanol and in the presence of acatalytic amount of acetic acid. Thiadiazol 14 was obtained in 65% yield after refluxing of Summary v 6 with carbon disulfide in methanol and in the presence of a sodium methoxide (Scheme 10). The ester derivative 15 was obtained by refluxing 14 with ethyl chloro acetate in alkaline medium / acetone in 72% yield (Scheme 11). Summary vi Chalcone 17 was synthesized by a base-catalyzed Claisen-Schmidt reaction between fulfuraldehyde and N-(4-hydroxyphenyl)acetamide in 70% yield (Scheme 12). The pyrimidine derivative 18 was obtained by refluxing 17 with urea in alkaline medium / ethanol in 68% yield (Scheme 13). The ester derivative 19 was obtained by refluxing 18 with ethyl chloro acetate in alkaline medium / acetone in 72% yield (Scheme 14). Summary vii Hydrazinolysis of 19 with hydrazine hydrate in ethanol afforded hydrazide derivative 20 in 66% yield (Scheme 15). The thiopyrimidine derivative 21 was obtained by refluxing 17 with thiourea in alkaline medium / DMF in 68% yield (Scheme 16). The ester derivative 22 was obtained by refluxing 21 with ethyl chloro acetate in alkaline medium / acetone in 72% yield (Scheme 17). Summary viii Hydrazinolysis of 22 with hydrazine hydrate in ethanol afforded hydrazide derivative 23 in 66% yield (Scheme18). Sugar hydrazone 24 was obtained in 65% yield after refluxing of 20 with D-(+)-glucose in ethanol and in the presence of a catalytic amount of acetic acid. Thiadiazol 25 was obtained in 65% yield after refluxing of 20 with carbon disulfide in methanol and in the presence of a sodium methoxide (Scheme 19). Summary ix The ester derivative 26 was obtained by refluxing 25 with ethyl chloro acetate in alkaline medium / acetone in 72% yield (Scheme 20). Sugar hydrazone 27 was obtained in 65% yield after refluxing of 23 with D-(+)-glucose in ethanol and in the presence of a catalytic amount of acetic acid. Thiadiazol 28 was obtained in 65% yield after refluxing of 23 with carbon disulfide in methanol and in the presence of a sodium methoxide (Scheme 21). Summary x The ester derivative 29 was obtained by refluxing 28 with ethyl chloroacetate in alkaline medium /acetone in 72% yield (Scheme 22). |