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المستخلص Alzheimer’s disease (AD) poses a significant challenge as a neurodegenerative disorder, primarily affecting individuals aged 65 and above. The intricate nature of the disease complicates the search for effective treatments. Currently, AD affects over 50 million people globally, and this number is expected to triple by the year 2050. Consequently, there is an urgent need for drug developers to discover effective anti-AD agents. Although the precise mechanism of AD remains uncertain, it is widely recognized that the disease is a complex syndrome resulting from various neurochemical factors. Several molecular mechanisms have been proposed, including the β-amyloid cascade, cholinergic dysfunction, as well as various other mechanisms and hypotheses that have been suggested and documented. The FDA has authorized five drugs for AD symptom relief, four of which are acetylcholinesterase (AChE) inhibitors: rivastigmine, galantamine, tacrine, and donepezil. Among these, donepezil stands out as the most favorable AChE inhibitor due to its unique benefits. The 1,2,3-triazole and its derivatives play a critical role as essential heterocyclic compounds extensively employed as pharmacophores in pharmaceutical drugs and diverse fields. Their biological activities have been extensively explored and validated through various studies. By incorporating donepeziltriazole with a sugar moiety, these compounds demonstrate the ability to effectively target and deliver drugs across the blood-brain barrier. |