الفهرس | Only 14 pages are availabe for public view |
Abstract Psoriasis is a chronic immune-mediated inflammatory skin disease with a strong genetic predisposition. It involves mainly skin and, in some cases, joints or nails can be associated with variant comorbidities of other systems. The exact etiology of psoriasis is not clearly known. It is a complex immune-mediated chronic inflammatory disorder that is triggered by various risk factors in genetically susceptible individuals. The pathogenesis of psoriasis is complicated, which involves the interplay between keratinocytes, immune cells, and other skin-resident cells. The interleukin IL-23/IL-17 pathogenic axis is the key to drive psoriasis. The cross-talk among immune cells and keratinocytes creates auto-inflammatory and pro-proliferative circuits mediated by cytokines that generate feed-forward loops driving inflammation. |