الفهرس 
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Abstract
Introduction :. Autoimmune thyroid diseases, comprising of Graves’ disease (GD) and destructive thyroiditis [Hashimito’s disease (HD)] are common autoimmune disorders. GD is characterized by a diffuse lymphocytic infiltrate in the thyroid gland with the presence of autoantibodies to thyroid antigens with those directed to the TSH-receptor (TSHR) being pathognomonic. The aim of the work: The aim of the present work is to investigate the relation between TSH receptor antibodies in Egyptian patients with GD and to evaluate its role in remission & relapse. Patients: This is a case-control study was conducted on 50 patients with GD. Their mean age was 31.64 years. They were 82% females and 18% males. In addition to 50 healthy control subjects, matched age, and gender in the period from February 2022 to February 2023; subjects were divided into three groups. Methods: the serum was separated and was kept at -20°C until be assayed for TSH receptor antibodies by Cobas e411 instrument electrochemiluminescence (ECL) method and this work was done in Clinical Pathology Department, Mansoura Faculty of Medicine. Results & Conclusion: The TRAb test is a sensitive test to differentiate between healthy subjects and GD patients at cut-off value (>1.5) and at cut off level (>3.93) can discriminate newly diagnosed cases from those under treatment. The TRAb titre not only aids in clinching a difficult diagnosis but can also help guide treatment in some patients. Although the TRAb assay has become more affordable in recent years, cost remains an important factor when considering its use routinely. Recommendations: Implementation of TRAb test in in clinical work up of hyperthyroid patients could help clinicians and improve the use of anti-thyroid therapy. Validation studies are required to detect the efficacy of TRAb test in monitoring anti thyroid therapy in GD patients and the best cut off level to diagnose remission state.