الفهرس 
Aim of the workOnly 14 pages are availabe for public view
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Abstract
Acute myocardial infarction (AMI) is caused by total, partial, or
transitory arterial occlusion caused by atherosclerosis coronary artery
plaque types of coronary artery disease (CAD). The hallmarks of this
disease are increased ST segments in the reflecting leads and higher
cardiac enzymes levels (Reed et al., 2017).
MI is a complicated disease marked by the inheritance of many
genetic variations that work together with environmental variables to
enhance disease progression (Maddhuri et al., 2018). Egypt is the
most populated country in the Middle East and North Africa,
accounting for almost 15% of the region’s cardiovascular deaths. In
Egypt, central obesity and smoking are exceedingly common,
resulting to higher burden of pre-acute coronary syndrome (ACS),
necessitating customized preventative efforts (Reda et al., 2019).
In comparison to other nations in the region and around the
world, Egypt has one of the highest rates of CAD- related death.
SMARCA4 gene (SWI/SNF related matrix associated, actin
dependent regulator of chromatine A4) located on chromosome 19,
encodes an ATP-dependent helicase BRG1 and it belongs to
SWI/SNF (switching defective/sucrose nonfermenting) complex
(Connor et al., 2020). This complex regulate transcription in an ATPdependent manner by disrupting histone –DNA interactions.
SMARCA4 is one of the most mutated cancer components (Wilson et
al., 2014). Its genetic polymorphisms have been linked to coronary
artery disease (CAD) and dyslipidemia-related illness in previous
study (Jamaldini et al., 2014; Genena et al., 2023)