الفهرس 
ACKNOWLEDGEMENTSOnly 14 pages are availabe for public view
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Abstract
Cyclophosphamide (CP) is a common cytotoxic agent that is employed as a chemotherapeutic and immunosuppressive drug for the management of several neoplastic, hematologic, and autoimmune diseases. Notwithstanding its efficacy in treatment, it exerts a lot of cytotoxic effects on several human organs. Ovarian toxicity is one of the most typical CP adverse effects in female cancer patients, potentially leading to infertility and ovarian failure. Infertility in women under the age of 40 is mainly caused by premature ovarian failure (POF), a degenerative ovarian condition that affects 1–5% of women. In this condition, the ovary suffers from continuum deterioration, leading to an earlier menopause than usual. Hormonally, POF is characterized by abnormal high FSH and low estrogen levels, indicating that the ovaries are no longer responding to circulating FSH by generating estrogen and developing fertile eggs. It’s likely that the ovaries appeared shriveled. Premature ovarian failure is accompanied by many severe complications, such as psychiatric distress, osteoporosis, auto-immune disorders, ischemic heart disease, and even a higher risk for death. Numerous variable factors contribute to POF, including genetic abnormalities, autoimmune disorders, metabolic problems, environmental factors, and iatrogenic factors (following ovarian surgery, radiotherapy, and chemotherapy regiments). However, about 74–90% of etiological factors remain idiopathic. Natural products have received great interest regarding the protection and regaining of ovarian functions and fertility in survivors of cancer. Among these products, the main carotenoid in saffron, crocin (Cr), finds special concern due to its unique properties, which make it act as a strong antioxidant, anti-inflammatory, antidepressant, and even anticancer agent. Crocin is also used in folk medicine as a sedative, eupeptic, anti-spasmodic, and aphrodisiac.