الفهرس 
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Abstract
Androgenetic alopecia is a common hair disease with genetic predisposition which is characterized by non-scarring progressive miniaturization of the hair follicle, accompanied by shortening of the anagen phase, leading to a gradual conversion of terminal hairs into vellus hairs with a pattern distribution.
Insulin resistance is a state in which a given concentration of insulin produces a less than expected biological effect. Obesity is the most common cause. This is followed by increased insulin secretion with compensatory hyperinsulinemia, to maintain normal glucose and lipid homeostasis. Insulin was suggested to play a role in the regulation of cutaneous androgen metabolism and hair growth cycle, which are relevant to AGA.
An association between AGA and metabolic diseases has long been postulated. AGA is the most common type of non-scarring progressive miniaturization of the hair follicle with a characteristic distribution pattern. AGA is highly associated to high-density lipoprotein cholesterol (HDL-C) as a most significant factor and insulin, secreted by the beta cells of the pancreas, is involved in glucose homeostasis, lipid metabolism, and anabolic processes by activating the insulin signaling pathways.
Zinc alpha 2 glycoprotein is a 40–43 kDa single chain polypeptide that is typically found in the majority of body fluids. Due to ZAG’s presence in a high number of body components, it has been suggested to play many roles in the body, including: fertilization, ribonuclease activity, cell adhesion, the regulation of melanin production, hindering tumor proliferation and promoting lipolysis (the hydrolysis of lipids into non-esterified fatty acids.