الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
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Abstract
After obtaining approval of the local ethics committee of faculty of medicine, Assiut University Hospitals, Assiut, Egypt, and patients’ written informedconsent, This randomized double –blinded prospective study conducted on 160women aged between 18 and 45 years with full term pregnancy, and of AmericanSociety of Anesthesiologist (ASA) physical status 1 or 2 scheduled for electiveCS under spinal anesthesia.
Women who have obstetric complications, or with evidence of fetal compromise, or have gastro-intestinal diseases, or who administrated anti-emetic medicationin the previous 24 hours before operation, were excluded from the study.About demographic data, there was no significant difference between the studgroups with each of age and BMI.
As regard hemodynamics in the both groups, the intraoperative SBP & DBP were comparable (P>0.05), but the heart rate in the cyclizine group was statistically(P<0.05) higher (although clinically insignificant) that in the dexamethasone group.
About first request of analgesia, there was no significant difference (P>0.05) between both groups.
The number and the severity of nausea attacks in the post-operative in the
postoperative period were significantly lower (P<0.024) in the cyclizine group.
On the other hand, there was no statistically significant difference between both groups (P=0.443) regarding the number of vomiting attacks at the end of 24hr. post-operative. Conclusion: cyclizine may be a good alternative to other well-known drugs for the prevention of postoperative nausea and vomiting in cesarean delivery under spinal anesthesia with intrathecal morphine.
Recommendation: a combination of cyclizine 25mg (to minimize the side
effect of the drug) and dexamethasone 4mg may be a good combination for further study.