الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
One of the main causes of morbidity and death in newborns admitted to the NICU is arterial and venous thromboembolism. According to reports, the risk of thrombotic problems during the neonatal period is 40 times higher than that of other pediatric age groups. The newborn’s exposure to several risk factors is the cause of the higher risk. Of these risk factors, 89% of neonatal thrombosis (NT) episodes are related to the presence of a vascular catheter.
The majority of the catheter-related thrombi are asymptomatic with rates
20-30% among all neonates with catheters. Other predisposing factors for NT include prematurity, perinatal asphyxia, sepsis, heart conditions and maternal diabetes.
This is a prospective cohort study was conducted to evaluate the clinical characteristics, the laboratory assessments, the predisposing risk factors and outcomes of neonatal thrombosis in neonates admitted to NICU Minia-University Children Hospital.
This study was conducted on 36 neonates diagnosed with neonatal thrombosis out of 1000 neonates who were admitted at NICU, Minia university Hospital from 1/2/2023 to 31/1/2024 in the age group from birth to 28 days old, The studied neonates were divided into 2 groups
• Thrombotic group: 36 neonates diagnosed to have established thrombosis
All neonates were subjected to full medical history, clinical examination and investigations ( CBC, CRP, blood culture, aPTT, and thrombophilia screening)
• Non-thrombotic group: 36 neonates with no history of thrombosis who were age and sex matched.
Our results showed that neonatal thrombosis is a multifactoreial event which occurs due to presence of more than one risk factor.
Neonatal thrombosis is usually associated with long duration of vascular access insertion, especially with umbilical venous catheter and central venous line.
This study stated that neonatal thrombosis is associated with longer duration of NICU admission and higher mortality rates.
Prematurity ,sepsis and mechanical ventilation are main risk factors. Maternal antenatal condition might have minor role as maternal HTN, DM and PROM.
On comparing the laboratory data between studied groups, there was statistically significance as regard TLC and CRP.
This study showed that treatment with LMWH may help to improve the outcome and decrease mortality rate.
This study demonstrated that thrombophilia gene screening have no role in neonatal thrombosis risk factors assessement except in cases with posiative family history of thrombovascular events.