الفهرس 
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Abstract
We aimed in our work to study Obesity and Insulin Resistance in
Treated Hypothyroid Patients Attending Menoufia University Hospital.
We included 254 hypothyroid patients under treatment, 31 males and
223 females divided into 2 groups obese and non-obese from period
December 2021 to December 2022 attended the endocrine department
Menoufia University Hospital.
Patient consent and ethical committee approval were taken.
All patient were prepared for weight, height, BMI, SBP, DBP, these
investigations: TSH, FT3, FT4, FBG, HOMA-IR, Anti-TPO, TGs, TC, LDLc, HDL-c, TLC.
Our results showed that 31 were males and 223 were female ratio all
were hypothyroid patients under treatment divided into 2 groups obese (149)
and non-obese (105) with a significant difference between both groups
regarding BMI, SBP, DBP. When we compared between both groups
regarding their laboratory data, we found that there was a significant
difference between obese and non-obese regarding FT3, FT4, FBG, HOMAIR, TGs, TC, LDL-C and non-significant difference between both groups
regarding TSH, Anti-TPO, HDL-C, WBCs, Neutrophils and Lymphocytes.
Then all the significant predictor factors of obesity between both groups
were entered into a regression model to ascertain their effect on obesity in
hypothyroid patients under treatment which showed that HOMA-IR, SBP,
TGs, DBP and FT4 in a descending manner were statistically significant
independent predictors of obesity and that HOMA-IR had the highest
adjusted odd’s ratio. Meanwhile the other factors were not significant in the regression model were (FT3, FBG, TC and LDL-C).
It meant that many factors may have a probability to obesity in
hypothyroid patients who receive their treatment and cannot lose weight so
we did this research to get these factors and then treat it and help hypothyroid
patients to get a satisfied weight and help them treat these factors and lose
weight. We found that the factors needed to be managed were: firstly, Insulin
Resistance., second factor was SBP., third factor was Triglycerides., fourth
factor was diastolic blood pressure and last factor is free T4. these results
show us that thyroid dysfunction was innocent from obesity occurrence in
hypothyroid patients as free T4 came in the last factor increased probability
of obesity in hypothyroid patients and even TSH level didn’t show any
significant relation to obesity in hypothyroid patients , these results
augmented the effect of other factors than hypothyroidism on obesity
occurrence and polished the importance of treating other factors like Insulin
resistance, blood pressure (systolic and diastolic) as ametabolic disease and
hypertriglyceridemia in the same line with normalization with free T4 to get
rid of obesity in that class of patients.