الفهرس 
Chronic Kidney DiseaseOnly 14 pages are availabe for public view
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Abstract
Chronic kidney disease (CKD) has become a global public health problem with an increasing prevalence and high mortality. Owing to the growing elderly population and the increasing prevalence of hypertension and diabetes as well as the improving treatment strategies, the prevalence of CKD will inevitably continue to increase soon. Glomerular filtration rate (GFR) and albuminuria are proposed as the best indicators of kidney function, with low GFR and increased albuminuria being associated with a high risk of kidney failure requiring renal replacement therapy and of cardiovascular disease, anemia, mineral and bone disorder, and other The pathophysiology of CKD is largely dependent on the primaryinsult, but common pathways exist across almost all subsets of kidneydisorders. The aim of studying the pathophysiology of CKD is to findapproaches to effective therapy for CKD. The kidney has an innate ability tomaintain GFR despite the progressive destruction of nephrons, as theremaining healthy nephrons manifest hyperfiltration and compensatoryhypertrophy. This nephron adaptability allows for continued normalclearance of plasma solutes.