الفهرس 
Acneيوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
Acne vulgaris is a widespread skin disorder that affects individuals of all ages, races and genders. characterized by the formation of comedones, papules, pustules, nodules and cysts. Acne can lead to physical discomfort, emotional distress and long-lasting psychosocial consequences. Although acne vulgaris is traditionally viewed as a predominantly dermatological concern, its pathogenesis is far from being solely skin deep. Emerging evidence suggests that this multifaceted condition may be influenced by a complex interplay of factors, including genetic predisposition, hormonal fluctuations, sebaceous gland activity and the immune response.
Adipokines, a class of bioactive molecules secreted by adipose tissue, have garnered considerable interest in the context of dermatological disorders, including acne vulgaris. Among the numerous adipokines, SERPINE1 (plasminogen activator inhibitor-1) and visfatin (nicotinamide phosphoribosyltransferase) have taken center stage in the exploration of their potential roles in the development and severity of acne.
SERPINE1, primarily known for its role in regulating fibrinolysis and coagulation, has also demonstrated the capacity to modulate inflammatory responses, which are closely intertwined with the pathophysiology of acne. Visfatin, originally characterized for its role in nicotinamide metabolism, has emerged as a multifaceted adipokine with immunomodulatory functions, making it an intriguing candidate in the context of skin inflammation and dermatological disorders.