الفهرس 
Diabetic Nephropathy
Blood Pressure ControlOnly 14 pages are availabe for public view
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Abstract
Diabetes mellitus is a metabolic disorder characterized by hyperglycemia resulting from defects of insulin action, secretion, or both. Longstanding diabetes is complicated with microvascular affection such as retinopathy, neuropathy, and nephropathy[1,2]. Diabetic nephropathy (DN) is a chronic complication of diabetes mellitus which may eventually lead to end-stage kidney disease (ESKD). In recent years, the spectrum of DN has been evolved. Our understanding of DN pathogenesis has been also advanced significantly[3,4]. Endothelial dysfunction plays an important role in the pathogenesis of diabetic vascular disease, including diabetic nephropathy.The regulation of nitric oxide (NO) synthesis is crucial for proper endothelial function. Endothelium-derived NO is important for the regulation of vascular tone[5,6]. Endothelial nitric oxide synthase (eNOS) gene polymorphisms that affect eNOS activity are associated with endothelial dysfunction. Among the various polymorphisms identified in the eNOS gene, three have been associated with microvascular complications of diabetes: the 786T > C substitution in promoter region (rs2070744), the 27-bp tandem repeat in intron 4 (VNTR intron 4 a/b), and the 894G > T (Glu298Asp) missense substitution in exon 7 (rs1799983). These polymorphisms have been associated with various stages of DN, from increased albuminuria to end-stage kidney disease (ESKD) in DN patients receiving hemodialysis[7,8]. Therefore, we tried in this study to evaluate the association of two eNOS gene polymorphisms in patients with type 2 diabetic nephropathy.