الفهرس 
Hashimoto Thyroiditis (Chronic Lymphocytic Thyroiditis)Only 14 pages are availabe for public view
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Abstract
This case-control comprehensive study aimed to enhance our
understanding of Hashimoto’s thyroiditis (HT); an autoimmune thyroid
disorder characterized by chronic inflammation of the thyroid gland. 100
HT patients and an age and sex-matched control group of 100 healthy
individuals were extensively examined in terms of demographic, clinical,
biochemical, genetic, and immunological parameters.
Key findings from this study include:
• Gender Bias: HT exhibited a significant gender bias, with a higher
prevalence in females, aligning with previous research highlighting
the vulnerability of women to autoimmune thyroid disorders.
• Clinical Manifestations: Clinical symptoms such as expressionlessness
and oral/genital ulcers were highly prevalent among HT patients,
underscoring the diverse clinical presentations of the disease.
• Biochemical Aberrations: Several biochemical parameters showed
significant differences between HT patients and controls, suggesting
the systemic impact of HT on various organ systems.
• Thyroid Function and Antibodies: Thyroid function tests and thyroid
antibodies demonstrated highly significant differences, confirming the
presence of thyroid dysfunction and autoimmune processes in HT
patients.
• Genetic Markers: Gene expression analysis identified significant
differences in ERN1 and EYA1, suggesting their potential role in the
pathogenesis of HT.