الفهرس 
CENTRAL NERVOUS SYSTEM DEMYELINATIONOnly 14 pages are availabe for public view
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Abstract
Background:
Pediatric central nervous system demyelinating diseases include multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), transverse myelitis and acute disseminated encephalomyelitis (ADEM) Children with CNS demyelinating diseases had an increased rate of psychotic disorders, anxiety, stress-related disorders, intellectual disability and other behavioral disorders. Psychiatric symptoms could occur at onset or during the disease course.
Psychometric evaluation is essential in pediatric patients with central nervous system demyelination for several reasons. Firstly, these conditions can have a significant impact on cognitive functioning. Demyelination disrupts the efficient transmission of nerve impulses, leading to cognitive impairments such as attention deficits, memory problems, and decreased processing speed. Psychometric assessment allows for the identification and monitoring of these cognitive deficits, which can inform treatment planning and provide valuable information for educational accommodations.
Aim:
The primary aim is to assess the psychiatric disorders in children with CNS demyelinating diseases, while the secondary aim is to assess quality of life of these patients.
Methods:
This is a cross-sectional case control study consisting of two groups, where the first group consisted of 28 children diagnosed with CNS demyelination who recruited from Child Neurology Clinic, Faculty of Medicine, Ain Shams University. And the second group has 28 control participants with matched age, sex and social class. In addition psychometric evaluation of diseased children was done using the Kiddie-Schedule for Affective Disorders and Schizophrenia (K-SADS), Child Behavior Checklist (CBCL), and Kid-Screen 27.
The inclusion criteria were patients’ age from 6-18 years old, children diagnosed as CNS demyelinating disorders. While the exclusion criteria consisted of patients had any systemic disorder, inborn errors of metabolis, and behavioral or developmental disease prior to CNS demyelination.
Results:
We found that CNS demyelinating diseases significantly affect psychiatric disorders in diseased children, not only that but it affects them in several aspects, such as depression, anxiety, somatic disorders, quality of life, school performance, behaviours, and social interactions. In addition, we found that age, school performance, socio-economic level, consanguinity, vision affection, IVIG and cytotoxic drugs exhibited positive associations with depression and anxiety.
Conclusion:
It’s concluded that psychiatric disorders frequency is significantly higher in pediatric patients with CNS demyelinating diseases, and it’s affected with various factors including age, school performance, socio-economic level, consanguinity, vision affection, IVIG and cytotoxic drugs.