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العنوان
Impact of tuberculosis on the outcome of kidney transplantation /
المؤلف
Ali, Mohamed Hesham Hamid.
هيئة الاعداد
باحث / محمد هشام حامد على
مشرف / محمد أحمد غنيم
مشرف / محمد عبدالقادر صبح
مشرف / فاطمة الحسينى مصطفى
الموضوع
Tuberculosis. Kidney transplantation.
تاريخ النشر
1995.
عدد الصفحات
322 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الطب الباطني
تاريخ الإجازة
01/01/1995
مكان الإجازة
جامعة المنصورة - كلية الطب - General Medicine
الفهرس
Only 14 pages are availabe for public view

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from 340

Abstract

The erroneous belief that tuberculosis is a very rare disease may account for the frequency with which the diagnosis of tuberculosis is missed or seriously delayed. This is accentuated by the fact that almost all clinical symptoms and radiologic changes may masked. The use of immunosuppressive drugs in renal transplant recipients results in major defects in host defences and an increased prevalence wide variety of infections. Mycobacterial infection was reported increasing incidence among kidney recipients and presents actual at the present time. Immunosuppressive drugs, especially steroids, are accused to predispose to tuberculosis in addition to other factors. Tuberculosis may occur early after transplantation and its clinical mani festations among kidney recipients can be masked, undefined, mild or polymorphic due to the blunted response to infection. Diagnosis of the tuberculous infection may be masked even after exhaustion of all investigations to deftne H and it may be diagnosed only after death. Antituberculous drugs developed serious problems among kidney recipients due to their nephrotoxicity hepatoxicity and drug interaction with the immunosuppressive drugs that may to adverse effect on the graft function. Prognosis of patients is dismal inspite of therapy and early diagnosis with effective, soon and complete treatment may be useful. Tuberculosis after kidney transplantation leads to serious problems that have develop a high morbidity mortality. It may be caused more commonly by reactivation of an qui scent focus rather than by denovo infection and also reported to be transmitted by the donor’s kidney.