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Abstract Sepsis syndrome is defined as the presence of two or more of the following criteria; Temprature 38°C or 36 °C, heart rate 90 beat per minute, respiratory rate 20 Breath/ minutes, white blood cell count> 12.0 x 109 / L or < 4.0 x 109 / L or > 0.10 immature forms (bands). The main causes of sepsis syndrome are divided into septic and aseptic causes;septic causes include for example -E coli in abdominal sepsis and aseptic causes for example prolonged chemotherapy and burns 40% of the total body surface area. Pathophysiology of sepsis syndrome were divided into three stages: stage I of cytokine production, stage II role of cellular interaction on the control of stage I, stage III fully developed (SIRS). In body metabolism during sepsis, glucose oxidation becomes impaired and lactic acidosis occure. Insulin resistance occure as a result of intracellular defect in glucose metabolism. Protein proteolysis with decreased protein synthesis except in the liver due to enchanced hepatic uptake of aminoacids. Fatty acids becomes a preferable source of fuel during sepsis. |