الفهرس 
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Abstract
locally advanced pelvic malignancies pose d’ifficult management Dlems. Although criteria for resectability vary widely, curative surgery not feasible in almost two thirds of patients with recurrent or advanced lcer (HoffmanOet ai, 1993). IIntraarterial infusion is suggested to take the advantage of the first f efface of chemotherapeutics, generating higher local drug ~centration at the tumor cell membrane and theorefore enhancing !ular drug uptake. Drug exposure to the tumor starts’ at the time of rug e through trough the cell membrane. Tumoriciodal effects were not ’eyed by presence of chemotherapeutics in the blood stream around or cells. Since uptake of the chemotherapy by the tumor is .. centration dependent, the aim should be to achieve optimal high local centrations via the arterial access. . To improve clinical response of intraarterial chemotherapy, the flow method is introduced. It is a technique whereby a balloon usion catheter is inflated in the artery to be infused to markedly ce blood flow to target tissue, resulting in higher drug delivery. In ’al models, higher regional tissue levels of 5-fluorouracil were ’eyed when the drug was infused with the stopflow technique than er simple intraarterial or intravenous infusion (Anderson et ai, 1981). Aigner described the feasibility of aortic stopflow infusion in anced pelvic malignancies (Aigner & Kaevel, 1994). Retarded blood