الفهرس | Only 14 pages are availabe for public view |
Abstract Thirty six patients of either sex were the subjects of this study. Their age ranged from 20-40 years. They were classified into three equal groups each was comprised of twelve patients. The patients of group I was given remifentanil in a dose of 1 μg/kg iv, while group II was given esmolol in a dose of 150 mg iv bolus dose, and group III was given 5ml saline prior to induction of anesthesia. In all patients, anesthesia was induced by propofol (2-2.5 mg/kg) followed by succinylcholine (1 mg/kg) to facilitate endotracheal intubation. Anesthesia was maintained with O2 : N2O in ratio of 1 : 2, halothane 0.5-0.75%. Muscle relaxation was achieved by an initial dose of atracurium 0.5mg/kg with top up doses of atracurium when needed. The assessment parameters were taken (SBP, DBP, MBP and HR) basal just before study drug, 1 minute after the study drug and1, 3 and 5 minutes after laryngoscopy and intubation. The present study demonstrated that remifentanil 1 μg/kg iv or esmolol 150 mg iv bolus [about 2 mg/kg], 1 minute before induction of anesthesia are equipotent in blunting increase in heart rate and arterial blood pressure after laryngoscopy and tracheal intubation. Furthermore, remifentanil presented a better hemodynamic stability than esmolol following laryngoscopy and tracheal intubation. |