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Abstract This work is done to outline pattern of glomerular diseases and efficiency of protocols of therapy in pediatric nephrology unit, Mansoura University Children Hospital. Patients were classified according to their clinical diagnosis. AGN is the most common glomerular disease (52%) in our unit followed by NS (37.6%). These results are parallel to epidemiological studies of Korea, Pakistan and South Africa but in contrast to epidemiological studies of Nigeria that found NS is the most common renal disorder followed by AGN. Revising the files of patients with NS reveals that: (1) PNS represents 88% of total nephrotic patients. (2) The most common cause of secondary nephrotic syndrome is SLE. These results are parallel to epidemiological studies of United Arab Emirates, Peru and Taiwan but in contrast to epidemiological studies of Korea that found nephropathy associated with Australia¬antigen-positive hepatitis the most prominent cause of secondary nephrotic syndrome. (3) Among patients with congenital nephrotic syndrome Finnish type is the most common and severe type. (4) Clinical characteristics of patients with PNS are as follows; Hypertension in 20% of patients, hematuria in 32%, hypocomplementemia in 1.9% and impaired kidney functions in 26% of patients with more affected males than females and the mean age of presentation is 5.3 years. These are similar to that reported by ISKDC, study of Saudi Arabia and study of Kuwait |