الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
Endometrial hyperplasia is an estrogen dependent lesion that is further classified as simple, complex or atypical depending on the degree or gland proliferation and the presence or absence of cytologic atypia. It is found that low risk of progression to endometrial carcinoma in patients wilh simple or complex hyperplasia without atypia (1 % and 3% respectively). The risk of concurrent or subsequent carcinoma increased to 8 % in patients with atypical simple endometrial hyperplasia and 29% in patients with atypical complex hyperplasia. Most patients who developed endometrial carcinoma in the setting of endometrial hyperplasia were associated with a favorable prognosis. This study was conducted from December 2000 to December 2001 and included 76 patients of pathologically proved endometrial hyperplasia. The cases were classified into 67 patients (88.2%) with simple hyperplasia without atypia, 4 patients (5.3 %) were complex hyperplasia without atypia, 3 patients (3.9 %) were atypical simple hyperplasia and 2 cases (2.6 %) were atypical complex hyperplasia. The aim was to measure the nuclear DNA content and to detect ploidy pattern of endometrial hyperplasia by FCM, also to find any possible correlation between DNA ploidy pattern and cell cycle kinetic of endometrial hyperplasia in differentiation between the types of endometrial hyperpalsia. DNA ploidy for all cases were diploid and DNA index (DI) ranging from 0.9 - 1. S-phase fraction and proliferation index were high in cases with atypical complex hyperplasia, atypical simple hyperplasia compared with Cases without atypia whether simple or complex hyperplasia and these differences were of statistical significance. We concluded that the study of the cell cycle kinetics by flow cytometry could pick up the group of patients with higher S-phase fraction and higher PI for strict follow up to minimize the cost and effort of surveillence. Long term studies are needed to prove or disprove the value or high S-phase fraction and PI as a predictor for development of endometrial adenocarcinoma. Recommendation: Further prospective studies with larger sample sizes and long duration of follow up using modern techniques for flow cytometry are needed to evaluate the value of this technique in this benign and potentially malignant lesion. Cell cycle analysis of all endometrial hyperplasia must be done to detect the cases with abnormal cell cycle kinetic. Long term follow up studies are needed to evaluate the prognostic value of high S-phase fraction and PI in cases of atypical endometrial hyperpalsia whether simple or complex.