الفهرس 
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Abstract
Endoscopic sinus surgery represents a great challenge nowadays and the associated intraoperative bleeding, especially under general anaesthesia provides an unsatisfactory surgical condition. This study was designed to compare the efficacy of propofol anaesthesia versus isoflurane in decreasing blood loss in endoscopic sinus surgery. Thirty patients comprised this study. They were ASA physical status I and II, of either sex with age, with age ranging from 20-50 years. The candidate patients were randomly allocated into two groups, 15 patients in each: ? The first group (Propofol group): Patients received induction dose of 2mg/kg propofol followed by continuous infusion 10mg/kg/hr for first 10 minutes, and then as 8mg/kg/hr for the next 10 minutes, and then was maintained on 6mg/kg/hr till end of surgery using syringe type infusion pump. All over the duration of surgery, fentanyl infusion started simultaneously with propofol infusion in a rate 1?gm/kg/hr using syringe type infusion pump. ? The second group (Isoflurane group): Patient received induction dose of thiopental Na (5mg/kg), and isoflurane 2%. In both groups anaesthesia was maintained by N2O:O2 of ratio 2:1 and atracurium for muscle relaxation. Routine intraoperative monitoring with ECG, non invasive blood pressure, pulse oximetry and ETCO2 was done. Estimation of Hb, hematocrite and platelets was performed preoperatively and 15 minutes after recovery. Blood loss was calculated using the patients’ hemoglobin concentration and iron content of the operative suction sample. ? There was an intraoperative decrease of hemodynamic parameters in the propofol group when compared with isoflurane group. ? There was a significant decrease in the estimated blood loss in the propofol group when compared with isoflurane group. We can conclude that propofol- fentanyl infusion is better in reduction of the blood loss than isoflurane inhalation anaesthesia for endoscopic sinus surgery.