الفهرس 
introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
This study comprised 50 patients with acute coronary syndrome, classified into AMI subgroup (34 patients) and Unstable Angina subgroup (16 patients). It also included 10 healthy persons as control group. All the study groups were subjected to clinical examination, ECG, serial cardiac enzymes, FBS, PPBS, blood picture, ESR, C-reactive protein, lipid profile, platelet count and size, platelet function and echo-cardiographic examination, and comparative evaluation of platelet function and morphology have been done. Significant changes in mean platelet volume, platelet distribution width and maximum aggregation ratio (ADP) was noticed when comparing group of patients with UA with that of control, AMI versus UA, and AMI versus control. A highly significant increase was in aggregates clumps in patients with AMI when compared to control group. However no significant changes were present in patients with UA when compared to control. There was significant increase in platelet volume and PDW in the subgroup with complicated AMI versus the subgroup of AMI without complications. There ware no significant changes in any platelet parameter when comparing diabetic patients with non diabetic. Platelet function and morphology can be considered as a reflection of the complex structure of the pathogenesis of ACS. But platelet morphology changes can be assessed more easily, so they may be used as a simple and feasible diagnostic method alternative to functions for evaluation of pathogenesis and complications of ACS.