الفهرس 
H pylori infictionOnly 14 pages are availabe for public view
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Abstract
Introduction: Helicobacter pylori has a worldwide prevalence being higher in developing countries. It is strongly associated with type B antral gastritis, peptic ulcer and gastric cancer and various extra-digestive diseases. Several seroepidemiological studies have suggested an association between IDA and Helicobacter pylori infection. Aim of work: evaluation of the changes of intragastric pH and ascorbic acid in patients with unexplained IDA and H pylori infection and evaluation of the effects of H. pylori eradication. Patients and methods: All patients with unexplained IDA were selected. Any selected patient presenting manifest causes of blood loss or any other non-gastrointestinal disease to cause IDA was excluded. All patients were submitted to thorough history taking, thorough clinical examination, upper gastrointestinal endoscopy through which multiple biopsies were taken for histopathological examination. Intragastric pH, JAA, and PAA were done to all patients. All participants gave a written informed consent. Three groups were included: group I: IDA positive/H pylori positive patients: group II: IDA positive/H pylori negative. group III: IDA negative/H pylori positive) Results: The prevalence of H. pylori infection and its associated chronic gastritis were higher in patients with than those without IDA. Also, we have found that in patients of group I, the reduction in gastric JAA concentration was associated with increased intragastric pH, dense H pylori colonization, dense corporal PMNs and MNCs infiltration, and significantly higher corporal score. Such alterations in intragastric pH and JAA might interfere with the process of iron absorption leading to IDA. H. Pylori eradication, there was a significant reversal of iron dependence and recovery from IDA in patients with chronic superficial H pylori gastritis but not in those with ABG. Conclusions: our findings indicate that patients with unexplained IDA associated with H. pylori gastritis present with alterations in the intragastric milieu, such as increased intragastric pH and decreased JAA. The concomitant occurrence of these two alterations may account for the impaired iron absorption and consequent IDA in these patients. These altrations were related to the severity of gastritis, presence or absence of atrophy, topography of gastritis, and H. Pylori colonization.