الفهرس 
INTRODUCTION and Aim of the work.Only 14 pages are availabe for public view
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Abstract
Objective: to initiate peristalsis in the Mayflower tissue bath<U+2122> and use this model to see the effect of different agents when in contact with the serosal or mucosal surface of a tubular segment of guineapig ileum. Substances safe for human use are tested and if effective, may be used in man to abolish peristalsis contributing to eneuresis in patients with neobladders Materials and Methods: guineapigs weighing 5001000 grams are decapitated and a 5 cm tubular segment is taken and mounted on a Mayflower organ Bath<U+2122> filled with Krebs solution. The latter is passed inside the lumen to initiate peristalsis by distension. The following substances were used: verapamil, capsaicin, guanethidine, 6hydroxydopamine, 57dihydroxytryptamine, botulinum toxin A, botulinum toxin D, conotoxin, agatoxin and ricin. Results: verapamil was effective in doses of 1.5 x 10 (5) M for periods ranging from 512 hours (average 6.5 hours). Capsaicin was effective in doses of 7.5 x 10 (3) M. Peristalsis was suppressed for an average of 8.9 hours. A mild effect was noted from dopamine and tryptamine and no significant effect occurred with the remaining substances. Conclusion: Using verapamil systemically and capsaicin by intrapouch instillation may help decrease peristalsis and hopefully help eneuritic patients who have neobladders.