الفهرس 
Introduction
Types of functionalized polymersOnly 14 pages are availabe for public view
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Abstract
The thesis comprises two main parts, the first part describes the synthesis of a novel group of polymericsupported prodrug analogues and the second part describes the synthesis of another group of some novel possible polymericsupported arylazo dyestuffs under the phase transfer catalyzed conditions (PTC). In the first part of the thesis we describe the total synthesis of a new polymeric backbonespacer conjugates and their use, via their latent active functions to prepare a novel group of polymeric reagents for the control releasing of some active drugs such as 5aminosalicylic acid, 2amino5methyl[1,3,4]thiadiazole, 4aminoantipyrene and Nsubstituted4aminobenzene sulfonamide derivatives into the gastrointestinal tract. The resulting prodrug analogues are insoluble in acidic medium but soluble in slightly alkaline medium. Hence, it is anticipated, during, in vivo testing of these possible chemotherapeutic agents by oral administration, to be insoluble in the gastric fluids, but will dissolve slowly in the intestinal medium. The ability of the hitherto synthesized prodrug analogues for releasing the active medicaments in presence of azoreductases is, for the time being, under intensive investigation. In the second part, we describe different chemical modifications on polymethyl methacrylate (PMMA) to produce, via chemical bonding with a group of different arylazo heterocycles, new colored and pigmented polymers. The prepared arylazo dyestuffs exhibited low solubility in most common organic solvents except nhexane, methylene chloride, pyridine and chloroform. This might form the basis to a possible new class of organic pigments. The accommodation of pyrazolone moiety in structure of such products might impart a good dispersibility and flow properties and/or better adhesive properties to the prepared polymeric dyestuffs with respect to their corresponding lowmolecular weight reagents. Structure of the prepared compounds was confirmed on the basis of spectral and elemental analytical data.