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العنوان
Effects of some drugs on the development of head region of albino mice during perinatal life /
المؤلف
El-­Etriby, Amira Hassan Abd El­-Raouf.
هيئة الاعداد
باحث / Amira Hassan Abd El-­Roouf El­-Etriby
مشرف / Ahmed Abd Raboh El­-Bayomy
مشرف / Mohamed Bahgat Hussein
مشرف / Hassan Ibraheim El-­Sayad
الموضوع
Antiepileptic drugs. Epilepsy. Diphenylhydantion. Carbamazepine. Pregnancy. Morphological abnormalities. Head Region.
تاريخ النشر
2004.
عدد الصفحات
158 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
علم الحيوان والطب البيطري
تاريخ الإجازة
1/1/2004
مكان الإجازة
جامعة المنصورة - كلية العلوم - Department of Zoology
الفهرس
Only 14 pages are availabe for public view

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Abstract

Epilepsy effects more than 50 million people worldwide, 5 million of whom have seizures more than once per month. In the present study, prenatal fetuses (14, 15, 17 day­ age) as well as delivered newly born maternally <U+2013> treated with the used antiepileptic exhibited a marked reduction of thier body weight, size, crown­rump length, head length & width and reduction of skull ossification comparing with those of the control. The used antiepileptic drugs reflected on wide range of morphological abnormalities in prenatal embryos (14, 15, 17 day­ age) and newly born exposed during utero life to either mono­diphenylhydantion or carbamazepine or combined therapy of both. The observed growth defects during prenatal growth, as well as in offsprings maternally treated with the used antiepileptic durgs may be attributed to the trasplacental passage of the drugs to the fetal tissues.