الفهرس | Only 14 pages are availabe for public view |
Abstract Epilepsy effects more than 50 million people worldwide, 5 million of whom have seizures more than once per month. In the present study, prenatal fetuses (14, 15, 17 day age) as well as delivered newly born maternally <U+2013> treated with the used antiepileptic exhibited a marked reduction of thier body weight, size, crownrump length, head length & width and reduction of skull ossification comparing with those of the control. The used antiepileptic drugs reflected on wide range of morphological abnormalities in prenatal embryos (14, 15, 17 day age) and newly born exposed during utero life to either monodiphenylhydantion or carbamazepine or combined therapy of both. The observed growth defects during prenatal growth, as well as in offsprings maternally treated with the used antiepileptic durgs may be attributed to the trasplacental passage of the drugs to the fetal tissues. |