Search In this Thesis
   Search In this Thesis  
العنوان
Study of the oxidant-antioxidant effects of parenteral nutrition in preterm neonates /
المؤلف
Nasef, Nehad Abd El-­Salam.
هيئة الاعداد
باحث / نهاد عبدالسلام ناصف
مشرف / محمد رضا بسيوني
مشرف / هاله محمد فوزي المرصفاوي
مشرف / هشام السيد عبدالهادي
الموضوع
Oxidation. Nutrition.
تاريخ النشر
2006.
عدد الصفحات
232 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
طب الأطفال ، الفترة المحيطة بالولادة وصحة الطفل
تاريخ الإجازة
1/1/2006
مكان الإجازة
جامعة المنصورة - كلية الطب - Department of Pediatrics
الفهرس
Only 14 pages are availabe for public view

from 267

from 267

Abstract

This study was a pilot study in a single blinded randomized control manner that involved 80 preterm newborns with mean gestation age of 31+ 1.8 weeks, range from 28 to 34 weeks, and admission weight of 1588+ 366 grams, receiving TPN. They were assigned to 4 different groups of TPN with different components; each group includes 20 preterm newborns. The first group received TPN mixture of dextrose and amino acids; the second group received TPN mixture of dextrose, amino acids and lipid emulsion; the third group received TPN mixture of dextrose, amino acids, lipid emulsion and multivitamins and the fourth group received TPN mixture of dextrose, amino acids, lipid emulsion , multivitamins and trace elements. Each group was further subdivided into two subgroups, each subgroup has 10 preterm newborns, with either light exposure or light protection and we measured the urinary peroxide level at 0 hour and 48 hours after the intervention. Our aim was to study the antioxidant effect of trace elements, as it includes some elements that have antioxidant properties like selenium, on decreasing the peroxide load in parenteral nutrition solution and their additive effect to light protection. Our primary outcome was measuring the urinary peroxide load using Ferrous Oxidation of Xylenol orange technique (FOX assay), and our secondary outcomes in this study were the correlation of oxidative stress with the development of NEC, CLD, sepsis and the impacts of the above parameters on the length of hospital stay and mortality.