الفهرس 
Introduction
AntioxidantOnly 14 pages are availabe for public view
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Abstract
In our ongoing research efforts to improve and develop new treatment strategies against inflammation and oxidative stress, we developed simple and efficient methods to synthesis a new derivatives as stable free radical scavenger through conjugation of the different moieties to enones 121a-g &138a,b (as starting compounds). It was consistent with our concept to create multifunctional antiinflammatory based on antioxidant activity and containing different active parts as indoline (122b,c & 133a-c - 135a-c), quinoline (126a-h), pyrimidine (128a-c), pyridine (139a,b) and coumarin (144 & 148). It seems reasonable to suggest that the antioxidant properties of the newly synthesised compounds may be a way to management of sever oxidative stress condition in the future, where oxidative stress cannot be adequately managed by the various component of the endogenous antioxidative defense system. The results of the biological part indicated that: 1. The most active antioxidant compounds 126a,b ,132, 133b, 134e,f, and 139a (general antioxidant assay) having hydroxyl or methoxy groups or both of them. 2. Increasing the size of heterocyclic ring lead to increasing the activity as quinoline and triazolothiadiazepine rings 126a,b and 132, respectively. 3. All the newly obtained pyrazolines 134b-f have high antioxidant activity in all antioxidant assay methods except compound 134a, this indicate the importance of this moiety as analogous to compounds 99&100 in introductive part. (Table 27).