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Abstract Oral glucdse tolerance test(ogtt), serum triglycerides (TG), and serum fibrinogen degradation products (FDPS) were estimated, biochemically, in twenty seven maturity onset diabetic female patients, before and after pentoxifylline (Trental) in adose of 400mg twice daily for fifteen days. Comparative study of the whole group of patients, revealed a significant reduction in the fasting, one hour, and two hours blood glucose levels, asignificant reduction in the serum triglycerides level, and an increase in the serum firinogen degradation products level. Only fifteen maturity onset diabetic patients of the whole group studied received their oral hypoglycaemic drugs along with pentoxifylline administration. In this group asimilar changes in the previous parameters were noticed. However, acomparison with twelve MOD patients without receiving oral hypoglycaemic drugs during the test, asignificant reduction in the serum triglycerides, and asignificant increase in the serum fibrinogen degradation products were noticed. |