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Abstract The present work was undertaken to study the histological and histochemical changes in the developing spinal and sympathetic ganglia of chick and rat embryos. 70 chick and 70 rat embryos were used. The spinal and the sympathetic ganglia of these embryos were taken at different embryonic stages. They were stained with Mallory’s Haemntoxylin, thiamine and Glees’ silver stains and for chromaffin reaction and acetyl cholinesterase enzyme activity. 3. It was found that the chick ganglion neurons started to differentiate earlier and became morphologically mature before the Be of the corresponding rat ganglia. The Nussle material in the chick spinal and sympathetic gangionic neurons was found to appear earlier than those of rat ganglia. It was first homogenously distributed in the cytoplasm and then became concentrated at the cell periphery with some per nuclear condense. |