الفهرس | Only 14 pages are availabe for public view |
Abstract The aim of present work is to study the association or linkage between primary congenital glaucoma (PCG) and HLA antigens in order to single out any genetic marker that can help in clinical setting of genetic counselling. The material included 82 individuals 22 were sporadic unrelated cases with PCG and 60 cases were the members of ten multiplex families having more than one sib affected with PCG. They comprised 20 parents (only one had PCG and was operated upon) and 40 sibs 21 with PCG and 19 normal. The paretnts of four families were consangenous two were first cousin and the other were second cousin. All of them were free from other disease that may had a genetic or immunologic relation. They were enrolled into two groups: I: Ten multiplex families. II: Thirty two unrelated patient with PCG, twenty two were unrelated sporadic patients and ten probands of the ten multiplex families. |