الفهرس 
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Abstract
Background: the aim of this study was to evaluate the efficacy and the effects of different types of infusates (normal saline as crystalloid, Haemagel as colloid and blood) in patients subjected to brain tumor resection. Patients & Methods: In this study, we compared the systemic haemodynamics, cerebral oxygenation and metabolic changes in 3 groups of patients suffering from brain tumors and admitted to the department of Neurosurgery in Mansoura University Hospital for elective resection of these tumors. This prospective randomized study was carried out on 60 patients of either sex with an age ranging from 20-60 years. They were randomly classified into 3 equal groups (20 patients each) according to the type of the maintenance infusate used. Results: Our results clarified that the 3 groups showed a comparably accepted intra-operative haemodynamic profile. Hb and HCT were noticed to be nearly stable during the whole study period with minimal significant decrease in crystalloid and colloid groups and minimal intra- and inter-group significant increase in blood group. As regards blood sugar and lactate, the 3 groups showed significant increases in both variables except for blood lactate in the colloid group that did not display any significant changes. The serum K+ showed a significant increase in blood and colloid groups in comparison to the basal reading and in comparison to other groups. Crystalloid group showed lowest values of SjO2 when compared with other groups. It was more or less within the physiological range in all groups. Noticeably, significant changes were existed in CaO2 (in all groups) and CjO2 (only in crystalloid group) nearly at all intraoperative monitored periods. Moreover, both colloid and blood groups demonstrated a loss of the CBF-metabolism coupling while in the crystalloid group flow-metabolism coupling was preserved. Finally, it is obvious that CEO2 decrease or increase (in conjugation with CMRO2) with the reverse occurs in CBFe. Meanwhile, the crystalloid and colloid groups didn‘t exhibit any significant change in the SjO2, CBFe, CMRO2 and CEO2 throughout the operative course in comparison to the basal value. Conclusion: All the 3 infusates used in this study had its own advantages and disadvantages. So, it is the art of anesthesiologist to use single type or a mixture of more than one infusate according to the patient‘s different parameters, systemic or cerebral.